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By Denham M.C., Whittaker J.

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Sleep and mortality: a population-based 22-year follow-up study. Sleep 2007; 30:1245–1253. 26. Kripke DF, Garfinkel L, Wingard DL, et al. Mortality associated with sleep duration and insomnia. Arch Gen Psychiatry 2002; 59:131–136. 27. King CR, Knutson KL, Rathouz PJ, et al. Short sleep duration and incident coronary artery calcification. JAMA 2008; 300:2859–2866. 3d] [13/7/010/22:15:31] [18–23] 2 Classification of sleep disorders “The time has come,” the Walrus said, “To talk of many things; Of shoes-and ships-and sealing waxOf cabbages-and kings-” Lewis Carroll: Through the Looking-Glass Sleep medicine is a young field and its nosology is far from fixed.

Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 1999; 98(4):437–451. 18. Mignot E, Lammers GJ, Ripley B, et al. The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. Arch Neurol 2002; 59:1553–1562. 19. Szymusiak R, McGinty D. Hypothalamic regulation of sleep and arousal. Ann N Y Acad Sci 2008; 1129:275–286. 20. Siegel JM. REM sleep. In: Kryger MH, Roth T, Dement WC, eds. Principles and Practice of Sleep Medicine.

Other stressors should be identified and any history of past abuse delineated. Details of tobacco, alcohol, caffeine, or illicit drug use should be obtained. Knowing the frequency of physical exercise and degree of exposure to sunlight can be relevant in understanding mechanisms of insomnia. Medical A past or current history of hypertension, cardiorespiratory or neurologic disorders, or upper airway disease or surgery, may be relevant. A history of changes in weight over time should be obtained.

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