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By Jacques Chrétien, Donald A. Enarson (auth.), Alimuddin Zumla BSc MB ChB MSc PhD FRCP, Margaret Johnson MD, FRCP, Robert Miller MB FRCP (eds.)

In the 15 years of the obtained immunodeficiency syndrome (AIDS) pandemic a lot has been learnt approximately its average heritage and issues. it truly is transparent that the lung is an important goal organ either for the human immunodeficiency virus (HIV), and a big selection of infectious and non-infectious pulmonary issues. loads of info at the epidemiology, microbiology, immunology, medical gains, analysis and administration of those pulmonary problems has collected in past times 15 years. Given the big explosion in details, it really is now well timed to compile this data during this 25-chapter quantity on AIDS and breathing drugs. The individuals to this quantity are favourite epidemiologists, medical professionals, microbiologists and scientists from Europe, united states and Africa. Professors Chretien and Enarson provide a masterful account of the epidemiology of lung problems of HIV. Drs Zumla, Rowland­ Jones and Professor McMichael supply a close precis of the lung immune responses to HIV. They define general lung defenses and speak about the results of HIV an infection on them. The pulmonary radiological positive factors of HIV and its problems as obvious within the united states and Europe are illustrated through Professors Armstrong and Dee and this is often in comparison and contrasted via Professor Tshibwabwa-Tumba who brings jointly his sizeable event of chest X-rays in AIDS sufferers from principal Africa. Drs O'Doherty and Miller care for the makes use of, and capability functions, of nuclear medication in imaging of the chest in AIDS patients.

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Zambello, R. , (1988) Phenotypical and functional analysis of bronchoalveolar lavage lymphocytes in patients with HIV infection. Am. Rev. Respir. , 138, 1609-15. , Zambello, R. and Trentin, L. (1990) Cytotoxic events taking place in the lungs of patients with HIV-1 infection. Am. Rev. Respir. , 142, 516-20. , Zambello, R. et al. (1992) Release of granulocyte-macrophage colony-stimulating factor by alveolar macrophages in the lung of HIV-1 infected patients. J. , 149, 3379-85. , Zambello, R. and Semenzato, G.

1993). , 1993) which include both Th1 and Th2 cytokine profiles and these are thought to represent uncommitted CD4 + cell populations. B LYMPHOCYTES B lymphocytes, responsible for humoral immunity, synthesize five major immunoglobulin classes (lgG, IgA, IgM, IgD, IgE) which form the pool of circulating antibodies (Bird, 1988). Poor humoral 18 Lung immunology and HIV immunity, absolute or functional, is associated with recurrent or chronic pulmonary disease and increased susceptibility to respiratory tract infections (Polmar, 1976).

Et al. (1982) Cell number and cell characteristics of the normal human lung. Am. Rev. Respir. , 126, 332-37. E. J. (1985) Evaluation of natural killer activity in patients with persistent and generalized lymphadenopathy and acquired immunodeficiency syndrome. Clin. Immunol. , 36, 141-50. V. and Toniola, A. (1992) Acute HIV-1 infection of CD4+ human lung fibroblasts. AIDS, 6, 232-34. , Evans, L. et al. (1988) Human immunodeficiency virus recovery from bronchoalveolar lavage fluid in patients with AIDS.

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