By Abhijit Chakrabarti, Avadhesha Surolia
Consists of serious reports and unique examine papers from the 2014 foreign Symposium at the "Biochemical function of Eukaryotic mobile floor Macromolecules". issues coated contain: · neurochemical and biochemical research of mobilephone floor glycoconjugates · membrane skeletal association · GPCRs and different receptors · biophysical methods to check membrane interactions · glycoconjugate metabolism · dysregulation · molecular mechanisms excited by cell-cell and cell-matrix interplay · glycans in infectious and neurological ailments · melanoma and glycosyltransferases as drug targets.
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Extra info for Biochemical Roles of Eukaryotic Cell Surface Macromolecules
Importantly, a large bleach area would reduce mobile fraction since it could bleach an entire domain resulting in total loss of fluorescence in such a domain (Fig. 5e, f). Analysis of fluorescence recovery kinetics of 5-HT1AR-EYFP in CHO cells with bleach areas of different sizes exhibited relatively constant diffusion coefficient and mobile fraction (Pucadyil and Chattopadhyay 2007b; see Fig. 6). This suggests that serotonin1A receptors experience a homogeneous membrane environment. Interestingly, FRAP experiments performed on cholesterol-depleted cells with an identical range of bleach area size showed a marked dependence of diffusion coefficient and mobile fraction of the receptor on the dimension of the bleach area (see Fig.
CRC, Boca Raton, FL pp 109–135 Edidin M, Stroynowski I (1991) Differences between the lateral organization of conventional and inositol phospholipid-anchored membrane proteins. A further definition of micrometer scale membrane domains. J Cell Biol 112:1143–1150 Ganguly S, Pucadyil TJ, Chattopadhyay A (2008) Actin cytoskeleton-dependent dynamics of the human serotonin1A receptor correlates with receptor signaling. Biophys J 95:451–463 Hagen GM, Roess DA, de León GC, Barisas BG (2005) High probe intensity photobleaching measurement of lateral diffusion in cell membranes.
This observation points out the potential of lateral dynamics as an indicator of progress of infection. In another study, HIV-1 fusion and entry into target cells have been shown to be dependent on the lateral mobility of CD4 receptors (which serve as one of the receptors for viral entry) in host cell membranes (Rawat et al. 2008). Conclusion and Future Perspectives Although we have discussed only representative examples of the application of FRAP in membrane and receptor biology, it is clear that this approach is capable of providing a variety of information depending on experimental design and question asked.