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Extra resources for Branching process models for surveillance of infectious diseases controlled by mass vaccination
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First pilot studies in patients who were treated during acute HIV-1 infection and subsequently went through structured treatment interruptions show that the HIV-1specific immune response could be boosted in these patients (Rosenberg 2000). Most patients were subsequently able to discontinue therapy and experienced at least temporal control of viral replication, with viral set points remaining below 5,000 copies/ml for more than 3 years in some patients. However, in the majority of individuals in this study (Kaufmann 2004), as well as in other studies assessing viral control following treated primary infection (Markowitz 1999), viral load rebounded during longer follow-up, requiring the initiation of therapy.