Download HIV Medicine 2006 by C. Hoffmann, J. Rockstroh, B. Kamps PDF

By C. Hoffmann, J. Rockstroh, B. Kamps

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Id=12491206 54. Lackritz EM, Satten GA, Aberle-Grasse J, et al. Estimated risk of transmission of the HIV by screened blood in the United States. N Engl J Med 1995, 333: 1721-5. id=7491134 55. Lee CA. The natural history of HIV disease in haemophilia. Blood Rev 1998, 12: 135-44. id=9745883 56. Lyles RH, Munoz A, Yamashita TE, et al. Natural history of HIV type 1 viremia after seroconversion and proximal to AIDS in a large cohort of homosexual men. Multicenter AIDS Cohort Study. J Infect Dis 2000, 181: 872-80.

Lancet 1986, 2:1113-5. id=2877269 61. Moore RD, Chaisson RE. Natural history of HIV infection in the era of combination antiretroviral therapy. AIDS 1999, 13: 1933-42. id=10513653 62. Murphy DA, Mitchell R, Vermund SH, Futterman D. Factors associated with HIV testing among HIVpositive and HIV-negative high-risk adolescents: the REACH Study. Pediatrics 2002, 110: e36. id=12205286 32 63. Padian N, Marquis L, Francis DP, et al. Male-to-female transmission of HIV. JAMA 1987, 258: 78890. id=3475478 64.

First pilot studies in patients who were treated during acute HIV-1 infection and subsequently went through structured treatment interruptions show that the HIV-1specific immune response could be boosted in these patients (Rosenberg 2000). Most patients were subsequently able to discontinue therapy and experienced at least temporal control of viral replication, with viral set points remaining below 5,000 copies/ml for more than 3 years in some patients. However, in the majority of individuals in this study (Kaufmann 2004), as well as in other studies assessing viral control following treated primary infection (Markowitz 1999), viral load rebounded during longer follow-up, requiring the initiation of therapy.

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